Minoxidil vs. Nanoxidil: The Difference Between Them

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nanoxidil vs minoxidil

You only have to look around you, or in your mirror, to see the effects of hair loss. But even if you know how common hair loss, is the numbers may still surprise you: 35 million men and 21 million women suffer from hair loss in the U.S.

For most people, hair loss is out of their control as genetics, age, and other factors contribute to thinning hair and, eventually, baldness.

That’s why hair loss products such as minoxidil and nanoxidil are so popular – because they can fight the effects of male and female pattern baldness while reducing the emotional distress associated with it.

We’ll discuss minoxidil vs. nanoxidil in this post while showing what they do to treat hair loss. We’ll also look into other factors, including the hair growth process.

Minoxidil vs. Nanoxidil: The scientific difference

While minoxidil and nanoxidil are different (and the same) in a lot of ways, a key difference is in their molecular structure. Nanoxidil has a similar molecular foundation as minoxidil but it has one less carbon chain.

In turn, that gives nanoxidil a larger molecular weight than minoxidil – which means it has a greater skin absorption capacity, as well.

Another key difference is that minoxidil focuses on treating the vertex (crown) area of the scalp while nanoxidil treats both the vertex and the hairline. The latter is good news for the many men who have a receding hairline.

Let’s take a deeper dive and examine minoxidil and nanoxidil more closely.

Minoxidil: The original

A couple of things you can say about minoxidil from the beginning:

  1. It’s backed by scientific research and trials,
  2. It’s the only over-the-counter hair loss solution recommended by the FDA
  3. It has a long history.

The Upjohn company – now Pfizer – created minoxidil in the 1950s as a way to treat ulcers and hypertension. But one of its interesting side effects was that it promoted hair growth.

From there, the rest was history as scientists channeled this information into creating a solution for fighting male pattern baldness.

How it works

One of the many interesting things about minoxidil is that scientists don’t quite understand how it works for stopping hair loss and promoting new hair growth.

But it’s considered a potassium channel opener which, in short, widens blood vessels and improves blood flow to the scalp.

As a result, minoxidil allows more blood, oxygen, and nutrients to hair follicles to help make them healthier and more able to thrive.

Hair that’s in the telogen phase of the hair growth cycle – which we’ll touch on a bit later – sheds and is replaced by thicker hair in the anagen (growth) phase.

Minoxidil primarily treats the top of the head (vertex), not the hairline. But it remains the most popular hair growth agent for men and women.

Minoxidil’s results

Minoxidil works by increasing blood flow to the scalp, which delivers more nutrients to the follicle that produces hair. The increased nutrient supply allows hair to grow longer than it normally would at its current rate of growth.

While scientists may not know exactly how minoxidil works, enough studies show that it does work. In a clinical study conducted by the FDA, 26% of men experienced moderate to dense hair growth by using the 2% minoxidil treatment for four months.

Other studies show that even better hair growth results when using the 5% minoxidil version. Which leads us to our next topic:

Minoxidil 2% vs. minoxidil 5%.

You can purchase minoxidil in either the 2% or 5% versions. The percentages indicate the amount of minoxidil contained in the product. The FDA approves both versions, but nothing above 5%.

While the 5% version is available to men, it’s not recommended for women because it may cause unwanted hair growth on other parts of the body.

What’s better? As you might expect, a larger dose of minoxidil has a greater impact on hair growth; one study showed that 5% minoxidil produced better results than the 2% version – up to 45% more hair regrowth in some participants.

The study even showed that participants had more positive psychological impressions of hair loss when using the 5% version.

The 5% minoxidil and 2% are the same in that neither is good for restoring growth or preventing hair loss along the hairline. Also, minoxidil isn’t effective if you have significant hair loss. It’s best for men or women over 18 who have gradually thinning hair.

4 Types of minoxidil

Minoxidil comes in four types: liquid, aerosol, foam, and minoxidil for beard treatment. Which one you choose depends on personal preference and the area of treatment.

  • Liquid minoxidil

Liquid minoxidil is the “original” and still widely used today. It contains propylene glycol, water, and alcohol, along with minoxidil.

It’s typically less expensive than other minoxidil types and many users say you need less liquid to cover an affected area as you do with foam.

  • Minoxidil foam

Some minoxidil users experience adverse reactions to the propylene glycol found in minoxidil liquid, which is the main reason for the development of minoxidil foam.

It’s convenient to apply and many minoxidil users feel that the foam is less messy and less greasy than liquid minoxidil overall. It also dries quickly.

  • Minoxidil aerosol

Aerosol minoxidil consists of a mixture of foam and liquid versions. It’s relatively easy to apply and comes in a 5% minoxidil formula. It’s not recommended for use by women.

  • Minoxidil beard treatment

Men with patchy beards may find it difficult to grow a full, lustrous face of whiskers. But minoxidil is among the products that may enhance beard growth, and scientific data shows that the 5% solution is effective for use on beards.

Check out Rogaine For Men if you think your beard hasn’t reached its full potential.

Minoxidil: The bottom line

There’s no denying that minoxidil helps many men and women in the fight against hair loss. While it’s still not clear how minoxidil works for treating hair loss and spurring hair growth, it does work for a lot of people.

Here are some things to keep in mind as you consider whether to use minoxidil or not:

  • It’s easy to get because you can purchase it over-the-counter without a doctor’s prescription. But it’s a good idea to check with a doctor before you buy it to determine the cause of your hair loss. Minoxidil won’t work if you have an underlying health condition that’s responsible for hair loss instead of the more common male and female pattern baldness.
  • Minoxidil is relatively easy to use, whether you purchase it in liquid, foam, or aerosol form. You can apply it directly to the scalp and it doesn’t take long to get the hang of its application.
  • You should use minoxidil twice a day, as recommended, to get the desired results. Applying it more than twice a day won’t bring better results; instead, you’ll waste product and have to buy a new bottle of it sooner than you should.
  • If you quit using minoxidil you’ll stop seeing positive results for treating your hair loss. It won’t continue to work, and you’ll have to keep applying it now and into the future because it doesn’t deliver permanent results.
  • Minoxidil’s results aren’t guaranteed but many men and women experience good results by using it consistently.
  • Minoxidil is particularly effective for younger men and women experiencing the early stages of hair loss.
  • Minoxidil treats hair loss on the top of the head and not a receding hairline.
  • Minoxidil isn’t overly expensive but it’s not cheap, either. A three-month supply of minoxidil 5% can cost around $40. But it would be a lot more expensive if you could only purchase it by prescription.
  • You can purchase minoxidil at most local drug stores, pharmacies, supermarkets, and online.
  • Rogaine is a common brand name of minoxidil – and it’s available in the extra-strength 5% version – but you can buy it in a variety of generic versions.
  • Patience is truly a virtue when using minoxidil because you may not see results for up to four months, and even longer in some cases. Stay with your daily minoxidil routine during those times of seemingly no progress.

Some precautions for using minoxidil

As with any drug, you should take care when using minoxidil while also understanding its potential side effects.

  1. Never use minoxidil if your scalp is swollen, infected, red, or irritated.
  2. Only use minoxidil made for your gender.
  3. Pregnant women shouldn’t use minoxidil without first seeking the advice of a doctor.
  4. It’s best to dry your hair and scalp before applying minoxidil.
  5. Only use minoxidil on your scalp unless you’re using the beard treatment.
  6. Avoid getting minoxidil in your eyes, nose, or mouth.
  7. While the risk of side effects is minimal when taking minoxidil you may experience lightheadedness, dizziness, a fast or irregular heartbeat, or numbness or tingling in the hands, face, or feet. If you experience any side effects, contact a doctor.

Nanoxidil: The minoxidil alternative

Nanoxidil is similar to Minoxidil but it uses nanoparticles instead of a topical solution. Nanoparticles are tiny particles that are only a few nanometers in diameter (one nanometer is one billionth of a meter). Nanoparticles are used in everything from sunscreen to cosmetics because they allow for better absorption through skin cells than traditional delivery methods.

Nanoxidil has been shown to be significantly more effective than Minoxidil at stimulating hair growth because it uses nanotechnology

While minoxidil’s roots extend to the 1950s, nanoxidil is a newcomer regarding hair loss and hair growth treatments.

Released in 2011 by Divine Skin Inc., nanoxidil represented an alternative to minoxidil and, its creators and others claimed, more effective treatment for hair loss.

The difference between nanoxidil and minoxidil lies in their chemical structure. Nanoxidil has a different molecular weight from minoxidil, and is responsible for opening the ion channels in the scalp. Its weight helps it to absorb more deeply into the scalp.

Another key difference between nanoxidil and minoxidil is that nanoxidil is useful for treating all areas of hair loss, not just hair loss on the scalp. That makes it a good option for men experiencing hair loss on their hairline.

Nanoxidil, unlike minoxidil, doesn’t have FDA approval, but it appears to have fewer side effects while producing positive results for men and women experiencing hair loss.

DS Laboratories, which includes nanoxidil in its Spectral DNC-N formula, says that 93% of people using nanoxidil saw a decrease in hair loss.

Spectral DNC-N

Spectral DNC-N

DS Labs’ Spectral DNC-N is the first topical hair-loss treatment that uses nanoxidil to fight hair loss.

Spectral DNC-N is said to work continuously over 12 hours – longer than most other treatments for baldness – and includes the DS Labs’ unique nanosome delivery system that delivers key ingredients more deeply into the skin.

The key compounds in Spectral DNC-N block dihydrotestosterone, a sex hormone that can lead to hair loss, while also encouraging hair growth at the hairline (as well as at the crown).

Spectral DNC-N also includes other helpful ingredients:

  • Retinol – which improves the absorption of the product into the skin.
  • Vitamin B2 – which helps treat a receding hairline.
  • Adenosine – which is used for cell optimization.
  • Copper peptides – which fight inflammation of the scalp.
  • Herbal extracts – which help to improve the overall health and condition of the scalp.

Nanoxidil: The bottom line

While nanoxidil, and Spectral DNC-N, is effective in treating hair loss, there’s still not a lot of information or studies about it, including whether it may have long-term side effects.

But, again, its short-term side effects are less than those of minoxidil – if it has any side effects, at all.

  • One of the advantages of using nanoxidil is that it treats the entire scalp area and not just the crown of the head.
  • People can use nanoxidil to not only deal with significant hair loss, but also as a preventive measure to retain their current hair while, hopefully, holding off future hair loss problems.
  • Nanoxidil is an excellent choice for women who, in many cases, are more sensitive to Minoxidil’s side effects (which is why women can only use a maximum minoxidil concentration of 2%).
  • Indeed, one of the reasons nanoxidil has become popular is that it’s said to have few, if any, of the side effects experienced by minoxidil users.
  • Nanoxidil includes other ingredients – such as aminexil, adenosine, and copper peptides – that improve hair growth. Minoxidil lotions, on the other hand, usually only contain minoxidil.
  • You apply nanoxidil to the scalp in the form of a topical lotion.
  • Recent studies show that nanoxidil is highly-effective in treating early female pattern hair loss without worry of increased scalp sensitivity.
  • Nanoxidil boosts hair count and hair density while reducing scalp inflammation.

Aminexil and stemoxydine

stemoxydine vs aminexil vs minoxidil
Source: https://www.minoxidilmax.com/

Aminexil and stemoxydine are two other compounds that have a similar molecular structure as minoxidil. Both are the creations of L’Oreal, the cosmetic company.

Aminexil treats hair loss by improving blood circulation to the scalp. It also helps to prevent the hardening and scarring of hair shafts that may lead to hair loss. It’s often used in conjunction with minoxidil.

Stemoxydine is another chemical that works similarly to minoxidil. It stimulates hair cells stuck in the dormant phase to enter into the anagen phase to continue their growth. Stemoxydine comes in a liquid form and is suitable for men and women.

The stages of hair growth

stages of hair growth

Part of understanding how hair products such as minoxidil and nanoxidil work is understanding the hair growth cycle. Considering that there are around 100,000 hair follicles on the scalp (and a whopping 5 million on the body).

As each follicle manufactures new hair, it pushes out the hair shaft to create longer hair. But not all hair grows at the same time, and each strand is in a different part of the cycle, which consists of four phases:

1. Anagen

The anagen phase is when hair is growing and represents the first stage of the cycle. During this phase, the cells of hair bulbs divide rapidly and create new hair growth. Studies show that up to 90% of hair follicles are in the anagen phase at any given time.

The anagen phase doesn’t pass quickly, mind you, but lasts between two and seven years. The length of the phase determines maximum hair length; hence, people with long hair have a longer anagen phase than many others.

Many factors determine the length of each individual’s anagen phase, including genetics, age, overall health, and lifestyle factors such as nutrition.

2. Catagen

Catagen is the transitional phase of the hair cycle and occurs after the anagen (growth) phase. It’s a short transitional phase that lasts two to three weeks and one in which hair stops growing and detaches itself from the blood supply.

3. Telogen

The telogen phase is one of “hibernation” in which the existing hair rests while new hair begins to grow beneath it slowly. This phase lasts for three months and up to 15% of all hair is in it at any one time.

4. Exogen

The final phase of the hair growth cycle is exogen in which hair sheds. Keep in mind that every hair on your head sheds eventually and most people lose 50 to 100 hairs each day.

Once hair sheds, the follicles transition back to the anagen phase where the cycle begins again.

It’s important to remember that, as mentioned, not every hair follicle is in the same phase at the same time. That’s a good thing considering that it keeps hair from shedding all at once.


Minoxidil and nanoxidil are different compounds that help treat hair loss and stimulate hair growth.

Nanoxidil, the newer of the two, produces similar results as minoxidil (if not better) and doesn’t have the same side effects – although it’s too early to tell if it has long-term side effects.

Is one better than the other? That’s a topic of much debate and there really isn’t a conclusive answer. What’s clear is that both products can decrease hair loss and help users to develop a thicker, fuller head of hair.

Do you use minoxidil or nanoxidil? If so, what are the results? As always, we’d love to hear from you.


About The Author

Domen Hrovatin
Domen Hrovatin

Domen—a self-confessed facial hair addict—is a grooming professional, style enthusiast, and someone with deep personal experience and knowledge about male pattern baldness. His work was mentioned in countless notable men's grooming and style publications, including Beardbrand and AskMen.

  • I have been using Nanoxidil for close to four months now. I have not seen an increase in hair loss but I have been having an inexplicable feeling of dizziness and lightheadedness. Can this be as a result of its increased absorption? Has anyone experienced this?

  • I have used Nanoxidil’s for the past 5 years or so. Absolutely NO SIDE Effects that I can honestly say.
    Has kept my hair growth steady at 65. No great improvement but no more hair loss.

  • Why can’t Nanoxidil be tested and approved by the FDA? Sure there is process, but that should be the right route for all drug or chemical-related products.

  • I was thinking the same thing. If it penetrates better than minoxidil, then you’re going to have more of it in your system which would cause side effects. I’m trying to figure out how to get rid of the bloated face.

  • All these boldly stated claims about Nanoxidil not rendering side effects, but with no scientific backing of why that is. If Nanoxidil’s primary mechanism of action is no different than Minoxidil’s, with the only difference being better absorption, I wouldn’t be surprised if the side effects are more pronounced…

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